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Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775 / E7080-G000-309 Per Merck Standard Convention [KEYNOTE-775]) - NCT03517449

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Study 309/KEYNOTE-775 Trial Design (Plenary Session #10191) Study 309/KEYNOTE-775 is a multicenter, randomized, open-label, Phase 3 trial (ClinicalTrials.gov, NCT03517449) evaluating LENVIMA in combination with KEYTRUDA in patients with advanced endometrial cancer following one prior platinum-based regimen in any setting.

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In KEYNOTE 775 130 patients had tumors that were MSI-H or dMMR and positive results were observed in the mismatch repair proficient (pMMR) subgroup and the microsatellite instability-high (MSI-H)/mismatch repair deficient group (dMMR).

Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775/E7080-G000-309 Per Merck Standard Convention [KEYNOTE-775]) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
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Study 309/KEYNOTE-775 Trial Design (Plenary Session #10191) Study 309/KEYNOTE-775 is a multicenter, randomized, open-label, Phase 3 trial (ClinicalTrials.gov, NCT03517449) evaluating LENVIMA in combination with KEYTRUDA in patients with advanced endometrial cancer following one prior platinum-based regimen in any setting. Pembrolizumab plus lenvatinib induced a statistically significant and clinically meaningful improvement in overall survival, progression-free survival, and objective response rate compared with chemotherapy in patients with advanced endometrial cancer after prior systemic therapy in the phase 3 KEYNOTE-775/Study 309 trial.